NOCIMED, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
Jeffrey C. Lotz,James Clayton Peacock, III,David S. Bradford,Stefan Dudli,Sergey G. Magnitsky
申请号：
US16224590
公开号：
US20190307393A1
申请日:
2018.12.18
申请国别(地区):
US
年份:
2019
代理人:
摘要：
An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).
