PROCÉDÉ DE PURIFICATION DE DÉRIVÉ DE BENZOPYRANE, FORME CRISTALLINE CORRESPONDANTE ET PROCÉDÉ DE PRÉPARATION DE LA FORME CRISTALLINE

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专利权人:

Hanlim Pharmaceutical Co.; Ltd.

发明人:

申请号：

EP16868887.7

公开号：

EP3381914A1

申请日:

2016.11.24

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention provides a process for purifying (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy -2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran, comprising converting an amorphous (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy -2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran to a crystalline form thereof. And also, the present invention provides a novel crystalline form of (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy -2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran and processes for preparing the same.

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中国工程科技知识中心

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