BERGER, MARK,THOMAS, KEISHA,SETH, SANDESH,LUDWIG, DALE LINCOLN
申请号：
CA3078963
公开号：
CA3078963A1
申请日:
2018.10.25
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
This invention provides a method for depleting a subject's hematopoietic stem cells comprising administering to the subject an effective amount of a radiolabeled anti-CD45 antibody, such as 131I-BC8 or 225Ac-BC8. This invention also provides a method for treating a subject afflicted with a non-cancerous disorder treatable via genetically edited cell therapy comprising (i) administering to the subject an amount of a radiolabeled anti-CD45 antibody effective to deplete the subject's hematopoietic stem cells, and (ii) after a suitable time period, performing the therapy on the subject to treat the subject's disorder. Finally, this invention provides articles of manufacture for performing the subject methods.
