This invention is directed to methods of using spiro-oxindole compounds of formula (I) as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.Wherein k, j, Q, R<1>, R<2a>, R<2b>, R<2c>, R<2d>, R<3a>, R<3b>, R<3c>, and R<3d> are as defined herein.