CHIMERIC NEWCASTLE DISEASE VIRUSES AND USES THEREOF

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专利权人:

Icahn School of Medicine at Mount Sinai

发明人:

ZAMARIN, Dmitriy,GARCIA-SASTRE, Adolfo,PALESE, Peter,FONG, Yuman

申请号：

EP15162322

公开号：

EP2987856B1

申请日:

2010.02.05

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The invention provides chimeric Newcastle disease viruses (NDV) engineered to express a heterologous interferon antagonist, a modified F protein, and a cytokine. Further provided are pharmaceutical compositions comprising such chimeric viruses, methods for producing said pharmaceutical compositions and their use in a method for treating cancer in a subject. Provided are also cells and non-human embryonated eggs comprising the chimeric NDV viruses of the invention.

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