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CHIMERIC NEWCASTLE DISEASE VIRUSES AND USES THEREOF
专利权人:
Icahn School of Medicine at Mount Sinai
发明人:
ZAMARIN, Dmitriy,GARCIA-SASTRE, Adolfo,PALESE, Peter,FONG, Yuman
申请号:
EP15162322
公开号:
EP2987856B1
申请日:
2010.02.05
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The invention provides chimeric Newcastle disease viruses (NDV) engineered to express a heterologous interferon antagonist, a modified F protein, and a cytokine. Further provided are pharmaceutical compositions comprising such chimeric viruses, methods for producing said pharmaceutical compositions and their use in a method for treating cancer in a subject. Provided are also cells and non-human embryonated eggs comprising the chimeric NDV viruses of the invention.
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中国工程科技知识中心
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