CHANG, Ye,상야,LI, Qing Ri,이경일,SEOL, Sang Ho,설상호,LI, Tie,이철,TONG, Chao,동초
申请号：
KRKR2018/004305
公开号：
WO2018/190659A1
申请日:
2018.04.12
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention provides a suspension comprising aluminum hydroxide and magnesium hydroxide and a preparation method therefor. An aqueous suspension composition according to the present invention ensures an excellent settling rate by using mixed suspending agents with a particular composition, so that insoluble aluminum hydroxide and magnesium hydroxide do not settle easily, form no cakes, and are easily re-dispersed. The aqueous suspension composition having an excellent settling rate not only has physical stability but forms a uniform dispersion system, thereby ensuring reproducibility or validity of bioavailability. Furthermore, the aqueous suspension composition according to the present invention provides an excellent texture, thereby increasing the drug compliance of a patient.La présente invention concerne une suspension comprenant de l'hydroxyde d'aluminium et de l'hydroxyde de magnésium et son procédé de préparation. Une composition de suspension aqueuse selon la présente invention garantit un excellent taux de sédimentation en utilisant des agents de suspension mélangés avec une composition particulière, de telle sorte que l'hydroxyde d'aluminium insoluble et l'hydroxyde de magnésium ne se déposent pas facilement, ne forment pas de gâteaux, et sont facilement redispersés. La composition de suspension aqueuse ayant un excellent taux de sédimentation non seulement a une stabilité physique mais forme un système de dispersion uniforme, ce qui permet d'assurer une reproductibilité ou une validité de biodisponibilité. En outre, la composition de suspension aqueuse selon la présente invention fournit une excellente texture, ce qui permet d'augmenter la conformité aux médicaments d'un patient.본 발명은 수산화알루미늄과 수산화마그네슘을 포함하는 현탁액 및 그 제조방법을 제공한다. 본 발명에 따른 수성 현탁제 조성물은 특정 조성의 혼합 현탁화제를 사용함으로써 우수한 침강률을 확보하여, 불용성의 수산화알루미늄 및 수산화마그네슘이 쉽게 침강하지 않고, 케이크(cake)를 형성하지 않으며, 재분산이 용이하게 해 준다. 우수한 침강률을 갖는 수성 현탁제 조성물은 물리적 안정성을 가질 뿐만 아니라 균일한 분산계를 형성하므로, 생체이용률의 재현성 혹은 유효성을 확보할 수 있다. 또한
