STEFAN EWERT,DAVID URECH,PETER LICHTLEN,ALCIDE BARBERIS,ADRIAN AUF DER MAUR
申请号：
PT11002906
公开号：
PT2390267E
申请日:
2006.06.06
申请国别(地区):
PT
年份:
2013
代理人:
摘要：
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF±, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF±, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF±-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
