A method and related apparatus (VS) for synthetic projection images, in particular synthetic 2D mammograms (S) formed from a 3D image volume T made up of slices (SL). It is proposed to compute a forward projection (FP) using a weighted average function that is implemented by a filter (FL). The filter function (FL) is configured such that that voxels in a slice with maximum sharpness are assigned highest weights thereby avoiding blurring by averaging with structurally less relevant slices.