Heather Elizabeth Burks;Jill Nunez;Bing Yu;Guo He;George Scott Tria;Yingchuan Sun;Stefan Peukert;Clayton Springer;Noel Marie-France Thomsen;Michael A. Dechantsreiter
发明人:
Heather Elizabeth Burks,Michael A. Dechantsreiter,Guo He,Jill Nunez,Stefan Peukert,Clayton Springer,Yingchuan Sun,Noel Marie-France Thomsen,George Scott Tria,Bing Yu
申请号：
US14178652
公开号：
US08877801B2
申请日:
2014.02.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to compounds of formula I:in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention； capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.
