Lawrence T. Boni;Vladimir Malinin;Xingong Li;Brian S. Miller
发明人:
Lawrence T. Boni,Brian S. Miller,Vladimir Malinin,Xingong Li
申请号：
US12748756
公开号：
US08802137B2
申请日:
2010.03.29
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 μm. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.
