LARSON ALYSSA M,LOVE KEVIN,WEIGHT ALISHA K,CRANE ALAN,LANGER ROBERT S,KLIBANOV ALEXANDER M
申请号:
IN201617011562
公开号:
IN201617011562A
申请日:
2016.04.01
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
Concentrated low viscosity low volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection rather than by lengthy intravenous infusion. These formulations include low molecular weight and/or high molecular weight proteins such as mAbs and viscosity lowering agents that are typically bulky polar organic compounds such as many of the GRAS (US Food and Drug Administration List of compounds generally regarded as safe) and inactive injectable ingredients and FDA approved therapeutics.