The present application provides Compound 1:, or a pharmaceutically acceptable salt or amino acid conjugate thereof. The present invention relates to an FXR activator and to methods of making and using said compound.本案提供化合物1:,或其醫藥上可接受之鹽或胺基酸軛合物。本發明係有關於FXR活化劑及該化合物之製造和使用方法。