A medical diagnostic system and method include a software application capable of generating medical data representing patient physiological information based on input signals received directly from one or more sensors. The application is capable of operating on a controller adapted to receive, store, and process the physiological information and may include a touch-screen, one or more auxiliary input devices, circuitry for obtaining position information from a location sensor, and a wireless transceiver to transmit data that may include patient physiological information over a wireless link. The controller may be capable of receiving voice input signals and manually entered input signals. A host may include a digital file for receiving and storing the wireless data, control logic to process the wireless data to generate a medical status of the patient, and a memory storage device for recording the medical status.