Elena Feinstein,Evgenia Alpert,Igor Mett,Amir Bar-Ilan,Igor Spivak,Hagar Kalinski,Natanja Slager
申请号：
US15645751
公开号：
US20170306329A1
申请日:
2017.07.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.
