KIM, SUNG WUK,JUN, SUNG SOO,JO, YOUNG GWAN,KOO, JA-SEONG,SUN, SANG OUK
申请号：
MYPI 20091211
公开号：
MY153027A
申请日:
2009.03.25
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
THE PRESENT INVENTION RELATES TO A FUNCTIONAL COMBINATION PREPARATION COMPRISING A DIHYDROPYRIDINE-BASED CALCIUM CHANNEL BLOCKER SUCH AS AMLODIPINE AND AN ARB (ANGIOTENSIN-2 RECEPTOR BLOCKER) SUCH AS LOSARTAN. IN PARTICULAR, THE PRESENT INVENTION RELATES TO A CHRONOTHERAPEUTICAL COMBINATION PHARMACEUTICAL FORMULATIONS WITH CONTROLLED-RELEASE FOR THE PREVENTION OR TREATMENT OF CARDIOVASCULAR DISEASE, WHICH IS FORMULATED IN ACCORDANCE WITH XENOBIOTICS AND CHRONOTHERAPY FOR ENABLING THE TWO DRUGS TO BE CHRONOTHERAPEUTICALLY RELEASED, THEREBY IMPROVING THE THERAPEUTIC ACTIVITY AS COMPARED TO THE CO-ADMINISTRATION OF EACH DRUG IN THE FORM OF A SINGLE PILL, WHILE REDUCING SIDE EFFECTS AND MAINTAINING THE THERAPEUTIC ACTIVITY AS HIGH AS POSSIBLE AT THE TIME OF DAY WHEN THE RISK OF A COMPLICATION OF CARDIOVASCULAR DISEASE IS HIGHEST.
