A substrate for cellular therapy to treat diseased or damaged ocular tissue, comprising:a non-porous polymer,wherein said substrate comprises a substantially homogeneous apical surface for the growth of cells,wherein the thickness of said substantially homogeneous apical surface ranges from about 0.1 to about 5 microns,wherein said substrate comprises an inhomogeneous basal surface comprising supporting features juxtaposed with said substantially homogeneous apical surface,wherein the height of said supporting features ranges from about 1 µm to about 500 µm;wherein said substrate is configured to support a population of cells suitable for the treatment of diseased or damaged ocular tissue, andwherein, upon implantation into a subject, said substrate supports said population of cells for a period of time sufficient to treat said diseased or damaged ocular tissue.細胞死、損傷または機能喪失を誘発する種々の疾患の治療を必要とする標的組織への細胞送達のための基材が、本明細書に開示されている。基材は、幹細胞を含めた播種された細胞を提供するように構成され、細胞と標的組織の相互接続およびその間の生体シグナルの伝達を可能にする構造支持体を有する。