One aspect of the present invention relates to aqueous surgical compositions comprising a sigma-1 receptor agonist. Another aspect of the present invention relates to methods of irrigating ocular tissues during an ophthalmic surgical procedure such as cataract surgery. Such methods comprise bathing the ocular tissues with a composition comprising a sigma-1 receptor agonist.本發明之一方面係有關於含西格瑪-1受體促效劑之水性手術用組成物。本發明之另一方面係有關於在眼手術程序(諸如白內障手術)期間注洗眼組織的方法。此等方法包括以含西格瑪-1受體促效劑之組成物沖洗該等眼組織。