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含有非肽鍵的混合型免疫球蛋白
专利权人:
Daniel J. CAPON
发明人:
Daniel J. CAPON
申请号:
HK16108696.2
公开号:
HK1220623A
申请日:
2016.07.20
申请国别(地区):
HK
年份:
2017
代理人:
摘要:
The present invention provides compounds, and methods for producing compounds having the structure:wherein A is a first polypeptide component of the compound; wherein C is a second polypeptide component of the compound, which polypeptide component comprises consecutive amino acids which (i) are identical to a stretch of consecutive amino acids present in a chain of an F<;sub>;c<;/sub>;domain of an antibody; (ii) bind to an F<;sub>;c<;/sub>;receptor; and (iii) have at their N-terminus a sequence selected from the group consisting of a cysteine, selenocysteine, CP, CPXCP (where X = P, R, or S), CDKTHTCPPCP, CVECPPCP, CCVECPPCP and CDTPPPCPRCP, wherein B is a chemical structure linking A and C; wherein the dashed line between B and C represents a peptidyl linkage; wherein the solid line between A and B represents a nonpeptidyl linkage comprising the structure:
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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