LI, Jianqi,CHEN, Xiaowen,MA, Zhilong,ZHANG, Li,CUI, Ning
申请号:
EP14794060
公开号:
EP2995617A4
申请日:
2014.05.08
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
Disclosed are benzoisothiazole compounds and a use in the preparation of anti-schizophrenia drugs. The benzoisothiazole compounds of the present invention not only have strong affinity for dopamine D 3 receptor, 5-HT 1A receptor and 5-HT 2A receptor, but also can observably improve the symptoms of schizophrenia relevant to apomorphine model and MK-801 model mice, with oral absorption being good, safety being high and side-effect being less, and having developmental value as new anti-neurotic disease drugs. The present invention is the compounds having a structure of general formula (I), or geometric isomers, free alkalies, salts, hydrates or solvates thereof.