BONDER CLAUDINE SHARON,LOPEZ ANGEL FRANSCISO,TALBO GERT HOY
申请号：
NZ60956711
公开号：
NZ609567A
申请日:
2011.11.07
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a composition comprising a population of cells enriched for non-adherent endothelial progenitor cells (EPCs) expressing a nucleic acid or protein selected individually or collectively from DSG2 and EMR2. Also disclosed is the use of an antibody or antigen binding fragment thereof that specifically binds to DSG2 and/or EMR2 or an immunogenic fragment or epitope thereof in the manufacture of a medicament for localising and/or detecting non-adherent EPCs in vivo. Further disclosed is an ex vivo method for detecting a non-adherent endothelial progenitor cell (EPC) comprising determining the level of expression of a nucleic acid or protein selected individually or collectively from DSG2 and EMR2 in, on or secreted from a cell, wherein an increased level of expression of a nucleic acid or protein selected individually or collectively from DSG2 and EMR2compared to another cell type is indicative of a non-adherent EPC.
