A tablet with differentiated oromucosal and enteric absorption comprises glutathione and/or its acetyl or proprionyl form； micro-granules each formed of an inner core of L-cysteine and/or its dimer L-Cystine, and an outer gastro-resistant coating consisting of a lipophilic matrix. The glutathione and/or its acetyl or proprionyl form may be present in the range of about 15% to about 30% w/w by weight of the tablet, and the L-cysteine and/or its dimer L-Cystine may be present in the range of about 1% to about 10% w/w by weight of the tablet. The tablet may comprise one or more surfactants, particularly those having a hydrophilic-lipophilic balance between 10 and 20, such surfactants can be selected from polysorbates, poloxamers, polyethylene glycol, di- and triethanolamine, glyceryl monosterate, soya lectin or sucrose esters. The gastro-resistant coating may be formed of hydrogenated vegetable fats, such as mono-, di- or triglyceride behanates, glyceryl palmitostearate, polyethylene glycol esters, particularly those wherein the hydrogenated vegetable fats have a melting point between 30°C and 100°C. The micro-granules can have a particle size of between 250 and 3000 microns. The tablet may further include nutritional supplements, such as vitamin C or selenium.
