STC.UNM;National Technology & Engineering Solutions of Sandia, LLC
发明人:
C. Jeffrey Brinker,Yu-Shen Lin
申请号：
US15023110
公开号：
US09855217B2
申请日:
2014.09.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
In one aspect, the invention provides novel monodisperse, colloidally-stable, toroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia basecatalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.
