Fungicidal mixtures, comprising 1) a fungicidal strain (I) selected from a) the Bacillus substilis strain with NRRL Accession No. B-21661, and b) the Bacillus pumilus strain with NRRL Accession No. B-30087, or a mutant of these strains having all the identifying characteristics of the respective strain, or a metabolite produced by the respective strain that exhibits activity against plant pathogenic fungi, and 2) at least one chemical compound (II), selected from the active compound groups A) to F): A) azoles; B) strobilurins; C) carboxamides; D) heterocyclic compounds; E) carbamates; F) other fungicides; in a synergistically effective amount, methods for controlling harmful fungi using compositions of components 1) and 2), the use of a component 1) with acomponent 2) for preparing such compositions, and also fungicidal agents and seed comprising such compositions.La presente invención se refiere a una composición fungicida para controlar hongos nocivos fitopatógenos, caracterizada porque comprende 1) una cepa fungicida (I) seleccionada de a) la cepa de Bacillus subtilis con el No. De accesión NRRL B-21661, y b) la cepa de Bacillus pumilus con el No. De accesión NRRL B-30087, y 2) al menos un compuesto químico (II), en donde el compuesto químico (II) es metrafenona en una cantidad sinergéticamente efectiva.