Popov Sergej Aleksandrovich,Попов Сергей Александрович,Pavlovskij Aleksandr Vasilevich,Павловский Александр Васильевич,Sysoev Dmitrij Sergeevich,Сысоев Дмитрий Сергеевич,Tlostanova Marina Sergeevna,Тл
申请号：
RU2016122727
公开号：
RU0002625275C1
申请日:
2016.06.08
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention can find application in treatment of malignant neuroendocrine tumours (NET) of the pancreas head (PH). Prior to surgery to remove the primary tumour, selective intraarterial oily chemoembolization of the pancreas head vessels is performed using 0.3 mg/kg of doxorubicin in 6-7 ml of lipidol, of which 1/3 of doxorubicin and 3 ml of lipidol are administered super-selectively into the tumour vessels. Simultaneously, intraarterial oily chemoembolization of blood vessels feeding the liver and NET metastases is performed using 0.4 mg/kg of doxorubicin in 6-7 ml of lipidol. Then, during surgery to remove the primary tumour, radiofrequency ablation (RFA) is also performed in the presence of a single large metastatic lesion or multiple metastases in the liver. After surgery, intraarterial oily chemoembolization of liver metastases is performed, using doxorubicin at a dose of 0.5-0.7 mg/kg in 5-10 ml of lipidol until remission is achieved, under the control of PET with radiopharmaceutical (RP) Ga-68 DOTATATE. If pathological accumulation of RP is detected in the tumour bed at a local relapse or when distant NET metastases are detected, antitumor treatment is conducted. The primary tumour of the pancreas head is removed as a standard pancreatoduodenal resection in isolated neoplasms or in the form of an extended operation with resection of surrounding organs and main vessels, or in the form of extended lymphadenectomy with minimization or absence of surgical influence on intrahepatic metastases. Ga-68 DOTATATE is used at a dose of 1.5 MBq/kg, but not less than 100 MBq per administration.EFFECT: method provides minimization of surgical treatment traumatism at high treatment efficiency.3 cl, 2 exИзобретение относится к медицине, онкологии и хирургии и может найти применение при лечении злокачественных нейроэндокринных опухолей (НЭО) головки поджелудочной железы (ПЖ). До оперативного вмешательства по удалению первичной опухоли проводят селектив
