A method of intubating a subject is disclosed. The method comprises insertingan endotracheal tube into the tracheal airway of the subject； inflating a cuffassociated with the endotracheal tube within the airway below the vocal cords；measuring a level of at least one measure being indicative of leakage ofsecretion past the cuff to the lungs； comparing the level of the measure withan optimal level of the measure； and adjusting inflation of the cuff based onthe comparison so as to generally minimize leakage of secretion from above thecuff to the lungs, while minimizing pressure associated damages to the airway.The measure(s) can be carbon dioxide concentration, a proxy measure from whichsuch concentration can be inferred, or the level of one or more additivesdelivered to a subject during intubation.
