[Problem]An object of the present invention is to provide a pharmaceutical composition that can improve prognosis after return of spontaneous circulation even after a lapse of a considerable period of time from the return of spontaneous circulation.[Solution]Provided is a gaseous pharmaceutical composition for improving prognosis after return of spontaneous circulation in a human subject after a lapse of 30 minutes or longer from the return of spontaneous circulation following cardiopulmonary arrest for at least 10 minutes. The pharmaceutical composition of the present invention comprises hydrogen gas, and the prognosis after return of spontaneous circulation is improved in a human patient group with the administration of the pharmaceutical composition as compared with a human patient group without the administration of the pharmaceutical composition.