AGENTS SE LIANT A L'INTEGRINE ALPHA-2 ET LEUR UTILISATION POUR INHIBER LA PROLIFERATION DES CELLULES CANCEREUSES

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

DUDLEY, DAVID T.,WEISS, STEPHEN J.

申请号：

CA2840175

公开号：

CA2840175A1

申请日:

2012.05.18

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The invention provides an integrin alpha-2 binding agent and methods of using an integrin alpha-2 binding agent to, e.g., inhibit proliferation of cancer cells, modulate tumor growth in a subject, inhibiting angiogenesis, or treating a fibrotic disorder. The invention further provides a method of producing an antibody, the method comprising propagating cancer cells in a 3-dimensional matrix； immunizing a mammal with the propagated cancer cells； and isolating an antibody from the immunized mammal. A method of identifying an agent that inhibits cancer cell proliferation also is provided.

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