The Childrens Medical Center Corporation;The Children's Medical Center Corporation
发明人:
WAGNER, Denisa D.,WONG, Siu Ling
申请号：
EP16740569
公开号：
EP3247386A4
申请日:
2016.01.19
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Embodiments of the technology described herein are based, in part, upon the discovery that NETosis, the formation of neutrophil extracellular traps (NETs) is increased in wounds, in organ fibrosis and in subjects with diabetes. Accordingly, methods for treating wounds, fibrosis and NET associated complications in diabetes are provided. The methods comprise administrating a therapeutically effective amount of at least one anti-NET compound to a subject in need of treatment, e.g. a PAD 4 inhibitor, a DNase, a histone-degrading enzyme； an inhibitor of chromatin decondensation； an antibody against a component of a NET； an inhibitor of NET release, a protease inhibitor, or an elastase inhibitor.
