A vitrectomy probe for removing vitreous material from an eyeball, having a longitudinal axis and an outer tube with a closed end and a lateral surface, at least one inlet port located proximate to the closed end and configured to allow the vitreous material to enter into the outer tube an inner tube arranged in the outer tube to relatively move with respect to the outer tube, the inner tube having an opening with a cutting profile through which the vitreous material can be cut and can enter the inner tube. A drive unit configured for causing the outer tube and the inner tube to move relatively with respect to each other, in such a way that the cutting profile cuts the vitreous material entering the inlet port.
