LEV DAVIDOVICH RASNETSOV,SHVARTSMAN, IAKOV YUDELEVICH,SUROVA, OLGA NIKOLAEVNA
申请号：
BR112013012910
公开号：
BR112013012910A2
申请日:
2012.02.06
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
fullerene derivatives of homo and heteropoly c60 amino acids, method for producing them and pharmaceutical compositions based on said derivatives the present invention relates to the pharmaceutical industry and medicine, specifically with new derivatives of homo fullerene and heteropoly c60 amino acids of general formula: c60 (h) k {nh (ch2) nc00-}, ({nh3 + (l) cooh)} x, where n = 2-5, x = 3, l = - (ch2) m, where m = 1-5, or - co (ch2) kch (nh2) -, where k = 1-2, characterized in that the compounds comprise groups of covalently linked amino acids and polar phonic forms of the amino acids, and also a method for producing said derivatives, and for the production of pharmaceutical compositions based thereon； the method for the production of fullerene derivatives of homo and heteropoly amino acids is based on the reaction of a nucleophilic bond of fullerene amino acids, forming fullerene derivatives of covalently linked amino acids, with the subsequent introduction of polar phonic forms of the amino acids； a pharmaceutical composition comprises, as active substance, honor fullerene derivatives and heteropoly amino acids of formula: clio (h), {nh (cha) nc00 -}, {nh3 + (l) cooh)} x, where n = 2-5 , x = 3, l = - (ch2) m „where m = 1-5, ou-co (ch2) kch (nh2) -, where k = 1-2.derivados de fulereno de homo e heteropoli aminoácidos c60, método para a produção dos mesmos e composições farmacêuticas com base nos referidos derivados a presente invenção relaciona-se com a indústria farmacêutica e a medicina, especificamente com novos derivados de fulereno de homo e heteropoli aminoácidos c60 de fórmula geral: c60(h)k{nh(ch2)nc00- },({nh3+(l)cooh)}x, onde n = 2-5, x = 3, l = -(ch2)m, onde m = 1-5, ou - co(ch2)kch(nh2)-, onde k = 1-2, caracterizado em que os compostos compreendem grupos de aminoácidos covalentemente ligados e formas fônicas polares dos aminoácidos, e também um método para produzir os referidos derivados, e para a produção de composições farmacêuticas com base neles；
