VENKATESAN, ARANAPAKAM M.,CHEN, ZECHENG,DEHNHARDT, CHRISTOPH M.,DOS SANTOS, OSVALDO,DELOS SANTOS, EFREN GUILLERMO,ZASK, ARIE,VERHEIJEN, JEROEN C.,KAPLAN, JOSHUA AARON,RICHARD, DAVID J.,AYRAL-KALOUSTIA
申请号：
CA2721692
公开号：
CA2721692C
申请日:
2009.05.21
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Compounds of formula I(I) wherein: R1 is (II) or (III)； and R2, R4, and R6-9are defined herein, and pharmaceutically-acceptablesalts and esters thereof. These compounds inhibit P13 kinase and mTOR, and maybe used to treat diseases mediatedby PI3 kinase and mTOR, such as a variety of cancers. Methods for making andusing the compounds of this invention are disclosed.Various compositions containing the compounds of this invention are alsodisclosed.
