Dean Madden;Lars Vouilleme;Prisca Boinguérin;Rudolf Volkmer;Patrick R. Cushing
发明人:
Dean Madden,Patrick R. Cushing,Prisca Boinguérin,Rudolf Volkmer,Lars Vouilleme
申请号：
US13124470
公开号：
US08415292B2
申请日:
2009.10.20
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.
