BONGARTZ Zhan-P'er Andre Mark (BE),БОНГАРТЗ Жан-Пьер Андре Марк (BE),LINDERS Joannes Teodorus Marija (BE),ЛИНДЕРС Йоаннес Теодорус Мария (BE),MERPUL Liven (BE),МЕРПУЛ Ливен (BE),VAN LOMMEN Gi Rozalija,BONGARTZ ZHAN-PER ANDRE MARK,БОНГАРТЗ Жан-Пьер Андре Марк,LINDERS JOANNES TEODORUS MARIJA,ЛИНДЕРС Йоаннес Теодорус Мария,MERPUL LIVEN,МЕРПУЛ Ливен,VAN LOMMEN GI ROZALIJA EHGEN,ВАН ЛОММЕН Ги Розалия Эг
申请号：
RU2009148796/04
公开号：
RU0002478628C2
申请日:
2008.06.05
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to compounds of formula (I) possessing a property of DGAT inhibitor, its N-oxides, its pharmaceutically acceptable salts and solvates, as well as to a based pharmaceutical composition and their application. In general formula (I) , A represents CH or N； a dash line represents an optional bond provided A represents a carbon atom； X represents -O-C(=O)-； -NRx-C(=O)-； -Z-C(=O)-； -Z-NRx-C(=O)-； -NRX-C(=S)-； Z represents C1-6alkandiyl； Rx represents hydrogen； Y represents -C(=O)-NRx- or -NRx-C(=O)-； R1 represents aryl1 or Het1； R2 represents C3-6cycloalkyl, phenyl, 2,3-dihydro-1,4-benzodioxynyl, or a 6-member aromatic heterocycle containing 1 or 2 N atoms wherein said phenyl or the 6-member aromatic heterocycle containing 1 or 2 N atoms may be optionally substituted by one, two, three or four substitutes with each substitute independently specified in a group consisting of halogen； C1-6alkyl, C1-6alkyloxy, C1-6alkylthio； C1-6alkyloxycarbonyl, nitro； mono- or di(C1-4alkyl)amino； R4R3N-C1-6alkyl； Het-C(=O)-C1-4alkyl； R3 represents C1-4alkyl； R4 represents C1.4alkyl； R5 represents hydrogen； C1-4alkyl； C1-4alkylcarbonyl； R6 represents hydrogen or C1-4alkyl； or R5 and R6 may be taken together with a nitrogen atom whereto bound to form a saturated monocyclic 5, 6 or 7-member heterocycle which may additionally contain one or more heteroatoms each of which independently specified in O, S, S(=O)P or N； and such heterocycle may be optionally substituted by C1-4alkyl； R' represents hydrogen or halogen； aryl represents phenyl or phenyl substituted by halogen, C1-6alkyl, polyhalogen C1-6alkyl； C1-6alkylxoycarbonyl； aryl represents phenyl or fluorenyl； each of said phenyl or fluorenyl may be optionally substited by one or two substitutes with each substitute independently specified in a group involving oxo； carboxyl； halogen； C1-6alkyl optionally substituted by carboxyl or C1-4alkyloxycarbonyl； C1-6alkyloxy； C1-6alkyloxycarbon
