The present invention relates to a patient off-bed notification system, which includes a pressure-sensitive sensor pad, a signal converter, and a signal transmitter. The pressure-sensitive sensor pad includes an upper conductive layer, a bottom conductive layer, and an insulating layer arranged therebetween, where the upper conductive layer and the bottom conductive layer can generate an electrical signal due to a pressure change. The signal converter is used to receive the electrical signal from the pressure-sensitive sensor pad and perform operational analysis to produce a corresponding patient status signal. The signal transmitter transmits the patient status signal from the signal converter to a server, and the server displays or/and stores corresponding information according to the patient status signal. Thus, patient's statuses in bed can be known at any time, and the harm caused when the patient leaves the bed alone can be minimized, thus effectively improving the work efficiency of caregivers.