The present invention relates to compositions, including membrane permeable complexes, comprising a Caspase 2 activation inhibitory peptide having the amino acid sequence AFDAFC as well as methods of using the same for the treatment of neurodegenerative conditions associated with apoptosis in the central nervous system, such as Alzheimers Disease, Mild Cognitive Impairment, Parkinsons Disease, amyotrophic lateral sclerosis, Huntingtons chorea, and Creutzfeld-Jacob disease.
