Disclosed herein are hand-actuated aerosol generators, having an adjustable two-compartment medicament container (20) that holds a medicament in a liquid or a fine dry powder form, and connects to a fluid passage a cap of said container with a jet-sprayer capacity a mouthpiece (6) through which a medicament released from said jet-sprayer (2) can be inhaled into the respiratory tract by a patient without leakage a hand-actuated positive air pressure supplier connected to the cap of said medicament container, and an optional spacer that increases inhalation efficiency.