The Trustees of Columbia University in the City of New York
发明人:
VUKELIC, Sinisa,TROKEL, Stephen
申请号：
EP16858413
公开号：
EP3319538A4
申请日:
2016.10.23
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage or cornea, without using a photosensitizer (e.g., riboflavin), by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of tissue. In an embodiment, the femtosecond laser operates in the infrared frequency range.
