LAUER, PETER M.,BROCKSTEDT, DIRK G.,DUBENSKY, THOMAS W., JR.
申请号：
CA2814176
公开号：
CA2814176A1
申请日:
2011.10.10
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to methods of inducing a T-cell response against a Plasmodium species antigen in a subject. These method comprise administering to a subject a composition comprising a bacterium which expresses one or more immunogenic polypeptides, the amino acid sequence of which comprise one or more amino acid sequences derived from wild- type Plasmodium LSA1, CelTOS, CSP, and/or TRAP sequences, wherein said amino acid sequences are derived by (i) codon optimization of the wild-type sequence for expression in said bacterium, (ii) deletion of at least one hydrophobic region present in the wild-type sequence, and/or (iii) in the case of LSA1 and CSP, minimization of repeat units present in the wild- type sequence.
