The invention concerns a device (1) for inserting a soft cannula (11) into the tissue of the body of a patient and at the same time fixing it to the skin of the body. It comprises a housing (2) having a contact face (3) carrying a layer (4) of skin compatible glue and a cannula arrangement (6) which is movably arranged within the housing (2) and provides the soft cannula (11) and a guiding needle (12) extending through said cannula for temporarily stiffening it and for providing a puncturing tip (9). The soft cannula (11) is fixedly connected to a holder element (7). The device (1) furthermore comprises drive means (8) for effecting an insertion movement of the cannula arrangement (6) from a first position, in which the puncturing tip (9) is set back relative to the contact face (3), into a second position, in which said puncturing tip (9) protrudes beyond the contact face (3). The contact face (3) is formed by a base plate (10) which is fixed to the housing (2) in such a manner that when the cannula arrangement (6) is in the second position, it is detachable from the housing (2). The holder element (7) comprises coupling means by which it is coupled to the base plate (10) when the cannula arrangement (6) is brought into the second position. By means of the device (1) according to the invention, the application of an infusion set at the body of a patient can be performed in a safe and easy manner and the insertion movement can take place with a higher speed compared to devices known from the prior art, resulting in a further reduction of the pain associated with the piercing of the skin.