使用GLP-1受體促效劑與抑胃肽受體(GIPR)結合蛋白之偶聯物治療或改善代謝病症之方法农业专利-农业学术服务平台

发明人:: CHENG, YUAN,郑　元,鄭　元,NETIROJJANAKUL, CHAWITA,奈提罗真那库尔　恰薇塔,奈提羅真那庫爾　恰薇塔,HOLDER, JERRY,霍德　杰瑞,霍德　傑瑞,WU, BIN,吴斌,吳斌,FALSEY, JAMES,法赛　詹母斯,法賽　詹母斯,HERBERICH, BRADLEY,贺伯瑞奇　布来迪,賀伯瑞奇　布來迪,SHAM, KELVIN,单　凯尔文,單　凱爾文,MI,郑元,鄭元,奈提罗真那库尔恰薇塔,奈提羅真那庫爾恰薇塔,霍德杰瑞,霍德傑瑞,法赛詹母斯,法賽詹母斯,贺伯瑞奇布来迪,賀伯瑞奇布來迪,单凯尔文,單凱爾文

摘要：: Methods of treating metabolic diseases and disorders using a composition comprising an antigen binding protein specific for the GIPR polypeptide conjugated to a GLP-1 receptor agonist are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises an antibody or functional fragment thereof comprising a cysteine at one or more conjugation site(s) wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue.本發明提供使用包含GIPR多肽特異性抗原結合蛋白與GLP-1受體促效劑之偶聯物的組成物治療代謝疾病及病症的方法。在各種實施例中，該代謝疾病或病症係2型糖尿病、肥胖症、血脂異常、葡萄糖含量升高、胰島素含量升高及糖尿病性腎病。在某些實施例中，該組成物包含在一或多個偶聯位點處包含半胱胺酸的抗體或其功能片段，其中該GLP-1受體促效劑經由該半胱胺酸殘基之側鏈偶聯至該抗體或其功能片段。