The present invention provides a topical composition for application to a keratinous tissue comprising a cosmetically or pharmaceutically acceptable carrier; one or more selected from potassium, zinc, calcium, rubidium disposed in the cosmetically or pharmaceutically acceptable carrier; and one or more peptides disposed in the cosmetically or pharmaceutically acceptable carrier.本發明提供一種施用至角質組織之局部用組合物,其包含化妝品或醫藥學上可接受之載劑;一或多種選自鉀、鋅、鈣、銣之物質置於該化妝品或醫藥學上可接受之載劑中;及一或多種肽置於該化妝品或醫藥學上可接受之載劑中。