Reijo Laaksonen,Kim Ekroos,Reini Hurme,Minna Jänis,Riikka Katainen,Kirill Tarasov
申请号：
US13332773
公开号：
US20120258123A1
申请日:
2011.12.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention inter alia provides a method, and uses thereof, of predicting statin-induced muscle toxicity or its complications, such as myalgia, myopathy and rhabdomyolysis, by detecting the lipid concentrations or lipid-lipid concentration ratios of a biological sample and comparing them to a control. This method has identified lipid markers that are more specific and sensitive in detecting these statin-induced muscle toxicity than the currently utilized clinical markers. Also provided is an antibody towards said lipids, and the use thereof for predicting, diagnosing, statin-induced muscle toxicity. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of statin-induced muscle toxicity.
