Provided is a pharmaceutical composition comprising an amino acid sequence YEKLLDTEI (SEQ ID No. 1), or a functional variant peptide, pH regulator, and filler thereof, said peptide being an active peptide for treating central nervous system injuries. Also provided is a pharmaceutical composition comprising a chimeric peptide, pH regulator, and a filler, said chimeric peptide comprising an active peptide and an internalization peptide. Also provided is a medical application of the pharmaceutical composition comprising an active peptide or a chimeric peptide.