599269 Disclosed is a pharmaceutical composition comprising particles of rhein (4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid, Formula I) or diacerein (diacetylrhein, 4,5-diacetyloxy-9,10-dioxo-anthracene-2-carboxylic acid, Formula II) or salts or esters thereof optionally one or more pharmaceutically acceptable excipients, wherein the particles have an average particle size from about 0.1 microns to about 30 microns wherein the rhein or diacerein or salts or esters thereof is not co-micronized with surfactant. Also disclosed is the method for making the pharmaceutical composition.
