2-0-METHYLADEN0SINE DERIVATIVES AND THEIR USE AS AGONISTS OR ANTAGONISTS OF AN ADENOSINE RECEPTOR

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专利权人:

BIOVITRUM AB (PUBL)

发明人:

SAVORY, EDWARD DANIEL

申请号：

NZ57330707

公开号：

NZ573307A

申请日:

2007.06.26

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a compound selected from (2R,3R,4R,5R)-5-[6-amino-2-(cyclopentylmethoxy)-9H-purin-9-yl]-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol, (2R,3R,4R,5R)-5-{ 6-amino-2-[(2,2,3,3-tetrafluorocyclobutyl)oxy]-9H-purin-9-yl} -2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol, (2R,3R,4 R,5R)-5-[6-amino-2-(2,5-difluorophenoxy)-9H-purin-9-yl]-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol, (2R,3R,4R,5R)-5-[6-amino-2-(3,4-difluorophenoxy)-9H-purin-9-yl]-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol (2R,3R,4R,5R)-5-[6-amino-2-[4-chloro-3-(trifluoromethyl)phenoxy]-9H-purin-9-yl]-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol,(2R,3R,4R,5R)-5-(6-amino-2-{ [(1S)-1-methylpropyI]amino} -9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol and (2R,3R,4R,5R)-5-[6-amino-2-(cyclohexylamino)-9H-purin-9-yl]-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol for treating pain and inflammation.

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