MILLER, TIMOTHY M.,DEVOS, SARAH,BENNETT, C. FRANK,RIGO, FRANK
申请号：
CA2866392
公开号：
CA2866392A1
申请日:
2013.03.14
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Disclosed herein are methods for reducing expression of Tau mRNA and protein in an animal with Tau antisense compounds. Also disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds. Such methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration Tau antisense oligonucleotides include Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy, Chronic Traumatic Encephalopathy, Epilepsy, and Dravet's Syndrome.
