PROBLEM TO BE SOLVED: To provide a method of screening oral control agents for skin sympathetic nerve activity or skin microcirculation.SOLUTION: A method of screening oral control agents for skin sympathetic nerve activity or skin microcirculation involves measuring TRPV4 activity control capacity under the presence of oral control agent candidate substances for skin sympathetic nerve activity or skin microcirculation, and selecting a candidate subject capable of controlling TRPV4 activity as an oral control agent for skin sympathetic nerve activity or skin microcirculation.SELECTED DRAWING: None