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Powders for Inhalation containing tiotropium, a procedure for the preparation, use thereof for preparing a Medicament and capsules for Inhalation containing
专利权人:
BOEHRINGER INGELHEIM GMBH & CO KG
发明人:
BECHTOLD-PETERS KAROLINE,WALZ MICHAEL,BOCK GEORG,DORR ROLF
申请号:
NO20022414
公开号:
NO331956B1
申请日:
2002.05.22
申请国别(地区):
NO
年份:
2012
代理人:
摘要:
Powders for Inhalation containing 0.04 to 0.8 per cent of tiotropium in Mixture with a physiologically Safe Auxiliary substance, Where The Auxiliary substance comprises a mixture of an Auxiliary substance thicker with average particle size of 15 to 80 microns and an Auxiliary substance More fine with an average particle size of 1 to 9 micronsBeing 1 to 20% the proportion of The Auxiliary substance Finer in the total amount of auxiliary materials.Procedure for the production of Powders for Inhalation mentioned above, which are mixed, in a First Stage, the portions of The Auxiliary substance thicker portions of the finest Auxiliary substance, and a mixture of substances Auxili subsubsiguiente Stage Ares obtained meets with tiotropium Salt.Using the powder for Inhalation for the preparation of a Medicament for the treatment of respiratory disease, particularly Asthma or COPD (chronic obstructive pulmonary disease: chronic obstructive pulmonary disease), and a Capsule for Inhalation (INH Fin with a quantity of cargo as 3 to 10 mg inhalation Powder above,In particular, with an amount of between 1.2 and 80 micrograms tiotropium.In this way, we obtain a Powder for Inhalation containing tiotropium which allows the application of the active substance with a high portion suitable for Inhalation and variability with a as small as possible, which possesses a good accuracy of dosing,To guarantee a good behavior of empty capsules and is characterized by a high degree of homogeneity and uniformity of the dispersibility.Oppfinnelsen angår pulveriserte preparater inneholdende tiotropium for inhalering, prosesser for fremstilling av dem så vel som anvendelse av dem for fremstilling av et farmasøytisk preparat for behandling av respiratoriske lidelser, spesielt for behandling av COPD (kronisk obstruktiv pulmonal sykdom) og astma.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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