Hydrophobic modified preS derived peptides of hepatitis B virus (HBV) and their use as HBV entry inhibitors and HDV entry inhibitors

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专利权人:

ハイデルベルク;ルプレヒト-カールス-ウニベルジタート ハイデルベルク;ルプレヒト－カールス－ウニベルジタート

发明人:

マイアー， ウォルター,ウルバン， シュテファン,マイアー, ウォルター,ウルバン, シュテファン

申请号：

JP2010543440

公开号：

JP5791900B2

申请日:

2009.01.26

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present invention relates to hydrophobic modified preS-derived peptides of hepatitis B virus (HBV) which are derived from a HBV preS consensus sequence and are N-terminal preferably acylated and optional C-terminal modified. These hydrophobic modified preS-derived peptides of HBV are very effective HBV entry inhibitors as well as HDV entry inhibitors and are, thus, suitable for the inhibition of HBV and/or HDV infection, prevention of primary HBV and/or HDV infection as well as treatment of (chronic) hepatitis B and/or D. The present invention further relates to pharmaceutical and vaccine compositions comprising these hydrophobic modified preS-derived peptides of HBV.

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中国工程科技知识中心

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