Method for co-registration of angiography and intravascular images, which intravascular images are in the form of a sequence of images obtained from an intravascular imaging device which is pulled back through a vessel, the method comprising the following steps: a) generating a three-dimensional reconstruction of the trajectory of the intravascular device within the vessel from two or more bi-dimensional angiography images of such vessel which have been obtained from different perspectives； b) determining a first position of an element of the device within the 3D reconstruction of the trajectory； c) correlating the position of such element with a correspondent point in the reconstructed trajectory during pull back； d) correlating each intravascular image of the sequence with a corresponding spatial position within at least one of the bi-dimensional angiography images. A corresponding system and computer program are also disclosed.
